Recent studies have shown that self‐explanation is an effective metacognitive strategy, but how can it be leveraged to improve students' learning in actual classrooms? How do instructional treatments that emphasizes self‐explanation affect students' learning, as compared to other instructional treatments? We investigated whether self‐explanation can be scaffolded effectively in a classroom environment using a Cognitive Tutor, which is intelligent instructional software that supports guided learning by doing. In two classroom experiments, we found that students who explained their steps during problem‐solving (...) practice with a Cognitive Tutor learned with greater understanding compared to students who did not explain steps. The explainers better explained their solutions steps and were more successful on transfer problems. We interpret these results as follows: By engaging in explanation, students acquired better‐integrated visual and verbal declarative knowledge and acquired less shallow procedural knowledge. The research demonstrates that the benefits of self‐explanation can be achieved in a relatively simple computer‐based approach that scales well for classroom use. (shrink)

The current research investigates a combination of two instructional approaches, tutored problem solving and worked examples. Tutored problem solving with automated tutors has proven to be an effective instructional method. Worked‐out examples have been shown to be an effective complement to untutored problem solving, but it is largely unknown whether they are an effective complement to tutored problem solving. Further, while computer‐based learning environments offer the possibility of adaptively transitioning from examples to problems while tailoring to an individual learner, the (...) effectiveness of such machine‐adapted example fading is largely unstudied. To address these research questions, one lab and one classroom experiment were conducted. Both studies compared a standard Cognitive Tutor with two example‐enhanced Cognitive Tutors, in which the fading of worked‐out examples occurred either in a fixed way or adaptively. Results indicate that the adaptive fading of worked‐out examples leads to higher transfer performance on delayed posttests than the other two methods. (shrink)

This research provides an exploratory investigation of whether gift/help-receiving contexts that elicit mixed emotional variants of gratitude can be distinguished from typical gratitude-eliciting situations in their associated appraisals, action tendencies, and psychosocial effects. We examined 473 participants (159 males, 312 females, 2 others; Mage = 31.07) using a one-way four-conditions between-subjects experiment. Participants were randomly assigned to complete recall tasks describing four different gratitude-eliciting situations. Emotions, cognitive appraisals, action tendencies, and general psychosocial outcomes were assessed. Relative to a control condition (...) involving receiving a gift or help (gift/help condition), receiving something at the expense of a benefactor (benefactor-inconvenience condition) elicited gratitude-guilt; receiving something with an expectation of return (return-favour condition) elicited gratitude-disappointment and gratitude-anger; while receiving a disliked gift or receiving assistance that made things worse (backfire condition) primarily elicited gratitude-disappointment while also eliciting gratitude-anger and gratitude-guilt. Each condition was differentiable from control in their appraisals, action tendencies, and psychosocial effects. Notably, contexts which elicited mixed emotional variants of gratitude were characterised by the co-occurrence of conflicting appraisals such as pleasantness and unpleasantness or goal-congruence and goal-incongruence. Additionally, the return-favour and backfire conditions were most dissimilar from control, and were associated with the most negative action tendencies and psychosocial outcomes. (shrink)

continent. 1.2 (2011): 129-135. Introduction Vincent W.J. van Gerven Oei Successions of words are so agreeable. It is about this. —Gertrude Stein Nachoem Wijnberg (1961) is a Dutch poet and novelist. He also a professor of cultural entrepreneurship and management at the Business School of the University of Amsterdam. Since 1989, he has published thirteen volumes of poetry and four novels, which, in my opinion mark a high point in Dutch contemporary literature. His novels even more than his poetry (...) are criticized for being inaccessible, which I generally take to be a compliment. It would be like saying that Fernando Pessoa is inaccessible, which he is not. Neither is Wijnberg. When we think of the combination economist-poet we are immediately reminded of the American poet Wallace Stevens, who, as the story goes, had two stacks of paper on his desk, one for contracts, one for poems. We also know that Stevens wrote on the economy and that questions of economy and insurance surface at multiple points in his poems. The following text is a very preliminary attempt to point at the intersections between poems, novels, business, and poetry in Wijnberg’s work. On the back cover of his novel De opvolging ( The Succession , 2005), Wijnberg states the following: “[This is] a novel for whomever is interested in the workings of a company as much as in the workings of a poem.” Wijnberg thus claims that the way in which a company “works” may be similar to the way in which a poem “works.” The question is the obvious one, what does this similarity consist in? De opvolging tells the story of company in which bosses and company doctors, secretaries, children, clowns, and beggars have tons of meetings, recite poems, perform plays, tell jokes, and succeed each other, climbing up and down in the company’s hierarchy. De opvolging is a novel in which the career of people follows the career of words. It resonates with Gertrude Stein's sentences, "Grammar. What is it. Who was it" (1975, 50). The words in Wijnberg's poems are like he characters in his novel. And if we keep in mind this allegorical reading of De opvolging , which is obviously only one of the possible readings, we may be able to understand some aspects of Wijnberg’s poetry. A repetition is already a pun. Look, that word is trying it again, as if it is afraid that by not doing it it would give up the hope that it will ever be able to do something. A pun is the opposite of the first word coming to the mind of someone who shouts it when he suddenly discovers something. (104) The repetition, the succession of the same word, is already a pun, a joke. The succession of the father by the son after the revolution is a joke. "Look he's trying it again!" The essence of a joke is a repetition. Archimedes’ “Eureka!” is its opposite. Poems can easily become jokes, depending on the way the words follow and repeat each other. In De opvolging , the careers of the bosses, good and bad secretaries, and company doctors easily become jokes, as they are “afraid that by not doing it [they] would give up the hope that [they] will ever be able to do something.” Not only the repetition, but also the distance and difference between the words in a poem, their cause and effect relations can be read as company relations. This becomes clear when we, for example, read the first lines of the poem “Cause, sign” from Het leven van ( The Life Of , 2009). A sign lets know what is going to happen, a cause lets it happen. If the sign also lets happen there is no reason to isolate it, because then I would isolate some- thing only because it’s different for me. If I didn’t have to write this myself, but would have secretaries to whom I could dictate it, I would be able to say more about it. (49) Upon reading the first two lines we can already conclude that any word may be cause or sign or both. If a sign is also a cause there is no reason to discriminate it, yet to the poet they are still different. This difference only becomes expressible the moment he would have a secretary. Just like in De opvolging , the secretary introduces a distance; not in a company but in a poem. Hence the difference between “good” and “bad” secretaries in a company, where the good secretary of one boss may be the bad secretary of another one. The more we can say about the bosses of the company, or signifiers of the poem, the greater the distance we introduce between them and us. We should take serious the relation between Wijnberg’s novels and poems. Although they operate on different scales, they explain and converse with each other. Another example may be the novel Politiek en liefde ( Politics and Love , 2002), which deals with the relation, precisely, between politics and love. In the novel, Nicolai, a lieutenant in the Dutch army, is sent to Africa on a military mission. Upon leaving a receives a letter from his father. Dear son, Don’t do anything stupid before your father has advised you to do so. Your mother asked me to write a wise letter. I have been looking for wisdom for half a day and haven’t found much. If you borrow a small amount from a bank you become the bank’s slave, but if you borrow a couple of millions and spend them as quickly as possible the bank becomes your slave. What I want to say is that you have to return from Africa in good health, and before you know it the world will be your slave [....] Signed with a kiss from your father. (88) The line, “If you borrow a small amount from a bank you become the bank’s slave, but if you borrow a couple of millions and spend them as quickly as possible the bank becomes your slave,” returns as the title of poem in Het leven van: “If I borrow enough money the bank becomes my slave” (12-3), which elaborates this theme. So both in the way that these poems are structured and in their subject matter, they refer to the structures of our economy, to the ever-continuing line of CEOs succeeding each other like words, to the distance between them introduced by bureaucracy, and giving and receiving as economical and poetical acts. Poem and economy map onto each other, as in another episode from De opvolging : Edward reads two of the beggar’s poems about presents. Of a holiday nothing remains, except for memories, and if some of them are bad I’d rather forget them all; if I get a present I’d rather get something that’s useful to me for a long time. If I may choose, I choose what I can use longest, long enough to partially forget that this was the present, because it feels bad when nothing is left of it. […] Giving away becomes destruction in the stock destruction economy [ voorraadvernie -tigings-economie ], that is a gift economy [ geschenkeneconomie ], encountering for the first time an economy in which there’s selling and buying on markets. Instead of destroying supplies someone can also quickly say that they aren’t worth anything anymore; if someone wants to take them I’d gladly give him something extra. In a stock destruction economy he is someone who each day wants to work more hours than his colleagues. If around a company there is a gift economy in which someone’s rank is determined and made visible by the gifts someone can give someone else, a company will be more often character- ized by an invisible or unclear system of ranks. (152) Two poems about gifts present two different economical models, described by Wijnberg with the terms “stock destruction economy” and “gift economy.” Here we immediately recall the opposition introduced by George Bataille’s work on the concept of expenditure in The Accursed Share , where a “general economy” would surpass the stock destruction economy based on scarcity (capitalism) and become a gift economy (potlatch) and an egalitarian (communist) society. These claims are made both on the level of the poems and in their discursive explanation. They follow each other and on each other. I would like to finish this introduction to Wijnberg’s writing with a translation from his novel De joden ( The Jews , 1999), which develops the story of Hitler abdicating as chancellor of the Third Reich, appointing philosopher Martin Heidegger as his successor. In a conversation with two Russian actor-spies, sent by Stalin to figure out the situation, philosopher Walter Benjamin describes the abdication scene. Maimon: You were there when Hitler resigned? Benjamin: In the room we’re right now. The desk and the chairs are new. After his resignation Hitler would like to take his furniture to his new house. Martin naturally agrees. It is a sunny day. Martin is very nervous and complains about the heat. Martin is wearing his best dark blue suit, not his professor’s robe. Hitler is wearing his uniform. We enter the room and Hitler gets up and embraces Martin. Martin is not very good at embracing. Hitler shakes his hand. Hitler’s cap is on the desk. The cap has a metal lining. Hitler has strong neck muscles. Hitler says: A man is unclean. He takes a bath. Does he make the bath water unclean? I say: a man is unclean. He steps into a river. A little further a man steps into the river; does he become unclean? Hitler nods. I say: a man is standing in music. Another man hears the music but also sees the first man moving on the beat of the music in a way that he is certain that the music would excite different feelings in him if he wouldn’t to see the first man. Hitler says: a man is clean, listens to music, is suddenly touched and he doesn’t know by what. The conversation ends in the way you know it ends. Hitler picks up his cap from the desk and puts it on Martin’s head. (73-4) Aware of the never ending debate on the question of Heidegger’s involvement in the Nazi regime, Wijnberg has the audacity to present the arguments of complicity in the religious terminology of cleanliness and uncleanliness, while at the same time recalling overtones of Hitler’s supposed love for Wagner, suggesting a relation between Benjamin and Hitler, and so on. The space of this introduction is to small to treat a novel like De joden , a reading of which together with passages from Philippe Lacoue-Labarthe's Heidegger, Art, and Politics: The Fiction of the Political , Jacques Derrida's Of Spirit , Christopher Fynsk's Heidegger: Thought and Historicity , and Avital Ronell's The Telephone Book would be extremely elucidating and potentially open new avenues in thinking Heidegger's emphasis on poetry after the fall of the Nazi empire. But at this point we will have to curb our curiosity and follow the poet himself. The themes of the relation between business and poetry, but also Chinese landscape painting, love, Indian and Japanese poetry, and Western philosophy are analyzed and assimilated in Wijnberg’s work without ever losing the clarity of expression. It may be that, according to Alain Badiou, the “Age of the Poets” is over, but its end (Paul Celan) has exactly brought a new balance between philosophy and poetry, and it is this playful, but nonetheless serious balance that makes one hope that one day Wijnberg’s complete oeuvre might become available to readers across the planet. Tiranë, Albania February 15, 2011 English translations (all of them translated by David Colmer, who is preparing an English collection of Wijnberg’s poems entitled Advanced Payment ): Poetry International Words Without Borders Green Integer Review from Het leven van ( The Life of ) THE LIFE OF KANT, OF HEGEL As if every day he takes a decision that is as good as when he’d been able to think about it all his life. The life of Kant, of Hegel, the days of the life of, select three or four of them. Tell what he has discovered during those days as if he were the last one who knew so little. Give me something that I can cancel against then I can prepare myself for it. The reward is that I may continue with what I’m doing, it doesn’t matter how long it takes. This has nothing to do with everything remaining the same if I say that I no longer want anything else. I wouldn’t be able to say in which one and the other occur in a way that I if I knew something to cancel that one against it wouldn’t be possible now. The stars above my head and being able to say what belongs to what if I’ve let them in. FOLLOWING MY HEART WITHOUT BREAKING THE RULES Observing the rules without observing the rules by going where the rules no longer apply. I could also observe the rules there by applying them to what at great distance may resemble what the rules are about. But why would I do that, not to confuse someone who is seeing me from a great distance? Behind this morning the morning prepares itself when the rules are everything I have. IF I BORROW ENOUGH MONEY THE BANK BECOMES MY SLAVE A bank lends me money, if I don’t pay it back they tell my boss that he has to pay them my salary. But they have to leave me enough to eat and sleep and an umbrella when it’s raining. They can also empty my house, the furniture isn’t worth a lot, but every little helps. Each morning I leave for work, if I don’t start early they’ll soon get someone else, no bank will lend me money when the sun is shining. My boss has given me a cat to raise as a dog. Of course I know that it won’t work out, but I’ve asked for a week—maybe the cat gets lucky, maybe I get lucky. My hands around a cup of coffee, before I leave for work, warm-empty, cold-empty, as if hidden in the mist over a lawn. What I make when there’s no work left for me, I’m ashamed to say how little it is. Once I’m outside I check it, if they watch out of the window they can see me doing it. Suppose it is so much that I’d stay counting for hours, it’s getting dark and I’m still there. They stay watching for a while once they’ve finished their work, but have to go home, I get that, sure, I could also go home and continue counting there. If it’s too little running back immediately won’t help, because nobody’s there anymore, and if I come back tomorrow I may have spent what’s missing tonight. Going somewhere where it’s warm enough to walk around without clothes during daytime, it helps me to know that something’s more there than here. For someone like me there’s work anywhere, it shouldn’t take a week to find work for me there. Three times work and a home close to work, I may choose one and try for a week whether I want to stay there. If at the end of the week I don’t want to stay I’m back on the next day, then it was a week’s holiday. RULES If that’s against a rule, it’s yet another one that I cannot observe, or only so briefly that I cannot re- member it later. Anyways the rules are only there to help me remember what I need in order to do better what I do. In that respect there’s no difference between the rules that I find in a book and the rules that I think of early in the morning. I know that because I’ve made a rule just now nothing has yet to observe it. CAUSE, SIGN A sign lets know what is going to happen, a cause lets it happen. If the sign also lets happen there is no reason to isolate it, because then I would isolate something only because it’s different for me. If I didn’t have to write this down myself, but would have secretaries to whom I could dictate it, I could to say more about it. If something is taken away from me I consider how it would be if the opposite had been taken from me. That is what causes or signifies what is farthest away from what is caused or signified by what has been taken away from me. note: For the translations of “The life of Kant, of Hegel” and “If I borrow enough money the bank becomes my slave” I was able to consult David Colmer’s wonderful translations. (shrink)

The Krüppel‐like factors (KLFs) comprise a family of evolutionarily conserved zinc finger transcription factors that regulate numerous biological processes including proliferation, differentiation, development and apoptosis. KLF4 and KLF5 are two closely related members of this family and are both highly expressed in epithelial tissues. In the intestinal epithelium, KLF4 is expressed in terminally differentiated epithelial cells at the villus borders of the mucosa and inhibits cell growth, while KLF5 is expressed in proliferating epithelial cells at the base of the intestinal (...) crypts and promotes cell growth. KLF4 and KLF5 respond to a myriad of external stress stimuli and are likely involved in restoring cellular homeostasis following exposure to stressors. Confirming their importance in maintaining tissue integrity, KLF4 and KLF5 are both dysregulated in various types of cancer. Here we review the recent advances in defining the physiological and pathobiological roles of KLF4 and KLF5, focusing on their functions in the intestinal epithelium. BioEssays 29:549–557, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:AQUINAS AND HEIDEGGER: THE QUESTION OF BIDLOSOPHICAL THEOLOGY VINCENT GUAGLIARDO, O.P. Dominican School of Philosophy and Theology Graduate Theological Union Berkeley, Oalifornia I N IDS BOOK, Hediegger and Aquinas: An Essay on Overcoming Metaphysics, John D. Caputo recommends a " deconstruction" of Aquinas' philosophical theology in order to let.the true ·element orf his thought, mysticism, come to the fore. Caputo argues persuasively that Aquinas' thought, expressed ·as.it is (...) in the garh of metaphysics, cannot escape Heidegger':s critique of met:aiphysfos as "onto-theo-logioal ". Aquinas, no more thoo.any other thinker of the West, has succeeded mavoiding this iorgorttenness. Those Thomi:sts who have tried to argue that Aquinas.is an exception rto this critique, Caputo oontends, have not succeeded in presenting their case. The verdict o.f Heidegger stainds. The on:ly reoourrse left is thart of deconstruction, which Capurto presents ais gaining mther than losing the true Aquinas precisely because deconstruction.allows us to move from the said (the metaphysical dimension) fo rbhe uil!said (the mystical dimension) of Aquinas' thought. The uns1aiid is the kernel, the center a;ro:und which whatever Aquinas says moves. It is the true dimension which his thinking il'eally seeks: union with God, in wh~ch both the union and God 1are themselves rineff1a;ble.1 There is, however,.a disturbing problem which I find wti:th Capui;o's conclusion. This problem does not have to do with his oonte!lltion that the true kernel of St. Thomas' thought!is mysticail. Ra.ther, the problem concerns what is being disen1 See John D. Caputo, Heidegger and Aquinas: An }j}ssay on Overcoming Metaphysics (N.Y.: Fordham University Press, 1982), pp. 211 & 247-8. 407 408 VINCENT GUAGLIARDO; O.P. gaged and put out of play tin the deconstrrucrb.ion, namely: philosophical thoology.2 What are the iimplicatfons of such a movie? Are they desirable for theology? Ought we and oan we, 1a;s Caputo suggests, disengage,and leave behind St. Thomas' philosophical theology because metaphysical without there being any true loss? Might we be facing a;n impoverishment of another kind: in a moI"e " radical " seeking of the dii.vine might we not be losing something m'a foI"getfulness of ourselves as,.after 1 all, omy human? ls not this something precisely the,realm of the humanitas of the homo huma,nus, which Heidegger 's thinking seeks Ito point out and draw us closer to, where humanitas refers to our necessary trelation to Heing, from whlch relation we as humans cannot detach ourselves so long as we are " auf die Erde "? 3 The ~oblematic In beginning our inquiry I would like to distinguish three different regions of human engagement in which the over1appii.ng of one onto the other ii.s not.always easy to discern: philosophy, phl1osopihioal theology and mysticism.. I want to say "iphilosophical theology " and not simply " theology " because I think that it ii.s not possible to thoologize without 1 at the same time also philosophiizing. I 1think St. Tihomas thought this as well. 'l\hat is why his theology was always philosophioa ;l, 1in dialogue wiith :the philosophers: Aristotle, the Platonists, Ma~monides and the Ail1abs. In saying this, however, I do not mean to,say that philosophy 1and theology 1 are 1 the same. Now the altemativce which Caputo would ha,ve us embrace, because presumably not onto-theo-logioal, is that of a "reli2 See Caputo, op. cit., 11 & 283. a" Die Wahrheit des Seins denken, heisst zugleich die humaniitas des homo humanus denken " (" Brief iiber den Humanismus," in W egmarken (Frankfurt am Main: Vittorio Klostermann, 1978), p. 349). This Latin expression is a.lso used by St. Thomas in De ente et essentia, III, to designate the formal principle (rationality) by which. the whole (an individual human being) becomes a whole. Also see In Met., VII, Leet. 5, nn. 1378-1380. THE QUESTION OF PHILOSOPHICAL THEOLOGY 409 giious 1alerthi0Jogy" of mysticism.4 One is.then led to ask whether and if,so, how, the same person could ibe hoth a philosopher and 1a mystic, i.e. both!a thinker and a person of [aith. Do they remain " existentially " opposed,,as... (shrink)

Henri J. Renard, S. J.: a sketch, by J. P. Jelinek.--The good as undefinable, by M. Childress.--Gottlieb Söhngen's sacramental doctrine on the mass, by J. F. Clarkson.--Christ's eucharistic action and history, by B. J. Cooke.--Objective reality of human ideas: Descartes and Suarez, by T. J. Cronin.--A medieval commentator on some Aristotelian educational themes, by J. W. Donohue.--God as sole cause of existence, by M. Holloway.--Knowledge, commitment, and the real, by R. O. Johann.--John Locke and sense realism, by H. R. Klocker.--The (...) being of nonbeing in Plato's Sophist, by Q. Lauer.--Ethics and verification, by R. McInerny.--Analogy and the fourth way, by J. J. O'Brien.--Love and being, by W. L. Rossner.--Complexity in human knowledge: its basis in form/matter composition, by E. L. Rousseau.--Toward a more dynamic understanding of substance and relation, by J. M. Somerville.--The origin of participant and of participated perfections in Proclus' Elements of theology, by L. Sweeney. (shrink)

According to M. W. Service (1978), prior to Patrick Manson’s (1844–1922) discovery in 1877 that the mosquito Culex fatigans (Diptera: Culicidae) was the intermediate host of Bancroftian filariasis, the association of insects with disease and the nature of disease transmission was almost entirely speculation. As biographers P. H. Manson-Bahr and A. Alcock (1927) put it: “Manson’s investigations were thus the first convincing evidence that the vague beliefs traditional among many untutored races and countenanced from time to time by a few (...) sagacious medical men—beliefs that various specific diseases of the blood are disseminated by bloodsucking insects—were of good pathological report and worthy of further thought” .. (shrink)

The volume includes the proceedings from the conference FOL75 -- 75 Years of First-Order Logic held at Humboldt University, Berlin, September 18 - 21, 2003 on the occasion of the anniversary of the publication of Hilbert's and Ackermann's Grundzuge der theoretischen Logik. The papers provide analyses of the historical conditions of the shaping of FOL, discuss several modern rivals to it, and show the importance of FOL for interdisciplinary research. While there is no doubt that the celebrated book marks a (...) most important step in the development of logic, the volume in hand proves the actuality of the question "Which logic is the right logic." The volume contains articles by: H. Andreka, J. X. Madarasz, I. Nemeti, A. Avron, K. Brunnler, A. Guglielmi, G. Englebretsen, W. Ewald, P. Hajek, J. Hintikka, W. Hodges, M. Kracht, R. Lanzet, H. Ben-Yami, C. Toke, S. P. Odintsov, H. Wansing, J. A. Robinson, M. Rossberg, M. Thielscher, D. E. Willard, andJ. Wole 'nski. (shrink)

We concur with Cohen Kadosh & Walsh (CK&W) that representation of numbers in the parietal cortex is format dependent. In addition, we suggest that all formats do not automatically, and equally, access analog magnitude representation in the intraparietal sulcus (IPS). Understanding how development, learning, and context lead to differential access of analog magnitude representation is a key question for future research.

Previous research on the use of diagrams for argumentation instruction has highlighted, but not conclusively demonstrated, their potential benefits. We examine the relative benefits of using diagrams and diagramming tools to teach causal reasoning about public policy. Sixty-three Carnegie Mellon University students were asked to analyze short policy texts using either: 1) text only, 2) text and a pre-made, correct diagram representing the causal claims in the text, or 3) text and a diagramming tool with which to construct their own (...) causal diagram. After a pretest and training, we tested student performance on a new policy text and found that students given a correct diagram significantly outperformed the other groups. Finally, we compared learning by testing students on a third policy problem in which we removed all diagram or tool aids and found that students who constructed their own diagrams learned the most. We describe these results and interpret them in a way that foreshadows work we now plan for a cognitive-tutor on causal diagram construction. (shrink)

Philosophy of science is the organized expression of a growing intent among philosophers and scientists to clarify, perhaps unify, the programs, methods and results of the disciplines of philosophy and of science. The examination of fundamental concepts and presuppositions in the light of the positive results of science, systematic doubt of the positive results, and a thorough-going analysis and critique of logic and of language, are typical projects for this joint effort. It is not necessary to be committed to a (...) belief that science and philosophy are or should be one, or else that “never the twain shall meet.” If anything, there is to be expected a wholesome regard for the value of established science in furnishing a foil for philosophy and a check on its old extravagances. This does not mean that even the best-established science may not be subject to most devastating criticism by analysis of its foundations. In fact, despairing of the philosophy of the schools, science has done it largely for itself. The theories of gravitation, atomicity, electro-magnetism, evolution, relativity and quanta have all arisen through drastic revisions of complacent fundamental “truths.”. (shrink)

“A New Budget of Paradoxes” will be a section of our Journal devoted to the pathological. It is not mere amusement. The old “Budget of Paradoxes,” edited by Augustus De Morgan is our model both for choice of material and for humaneness toward the Don Quixotes of Thought.

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley (...) Periodicals, Inc. (shrink)

Past research has provided some evidence of positive relationships between leisure and cognitive functioning, but questions remain regarding their mechanisms. We argue that specific negative emotio...

Organic chemists have been able to develop a robust, theoretical understanding of the phenomena they study; however, the primary theoretical devices employed in this field are not mathematical equations or laws, as is the case in most other physical sciences. Instead it is diagrams, and in particular structural formulas and potential energy diagrams, that carry the explanatory weight in the discipline. To understand how this is so, it is necessary to investigate both the nature of the diagrams employed in organic (...) chemistry and how these diagrams are used in the explanations of the discipline. I will begin this paper by characterizing some of the major ways that structural formulas used in organic chemistry. Next I will present a model of the explanations in organic chemistry and describe how both structural formulas and potential energy diagrams contribute to these explanations. This will be followed by several examples that support my abstract account of the role of diagrams in the explanations of organic chemistry. In particular, I will consider both the appeal to ‘hyperconjugation’ in the explanation of alkene stability and how the idea of ‘ring strain’ was developed to explain the relative stability of cyclic compounds. (shrink)

i went to my first meeting of this Society in Seattle in 1984, just forty years ago. Joe Grassi and Morris Grossman from Fairfield University picked up a group of us at the airport and headed to Seattle University. After going around the same block four or five times, Morris, who was riding shotgun, said to his colleague, “Joe, we’re lost.” Being an Italian American male (Baldwin 166–69), Joe emphatically denied this. We nonetheless pulled over, not knowing where we were (...) (some of us knew we did not know our location; one person apparently did not), and Morris and Joe continued their argument about our whereabouts. During the course of what was anything but a Socratic dialogue, two individuals in uniform came up to... Read More. (shrink)

The death of Jesse Gelsinger in 1999 during a gene therapy trial raised many questions about the ethical review of medical research. Here, the author argues that the principle of justice is interpreted too narrowly and receives insufficient emphasis and that what we permit in terms of bodily invasion affects the value we place on individuals. Medical research is a societally supported activity. As such, the author contends that justice requires that invasive medical research demonstrates sufficiently compelling societal benefit. Many (...) consider this societal benefit to be self evident. However, medical research is a complex activity; it yields new treatments but also creates financial rewards and affects health resource allocation. As research evolves into a multibillion pound, multinational enterprise, justice requires a much broader analysis of societal benefit. Without such evaluation we risk undermining the value of bodily integrity and of research participants. (shrink)

In his pioneering work of moral phenomenology, K. E. Løgstrup offered a phenomenological articulation of a central moment of ethical life: the experience in which “one finds oneself with the life of another more-or-less in one’s hands”. In such circumstances we encounter what Løgstrup calls simply the ethical demand. Løgstrup’s preferred formulation of the content of that demand is taken from the Bible: Love thy neighbor. This neighborly love is expressed in the form of spontaneous, selfless care for the other. (...) We shall have occasion in what follows to return to the content that Løgstrup associates with the ethical demand, but my primary focus here is not its content but its distinctive modality. Løgstrup specifies that modality in a fourfold analysis: the ethical demand is radical, silent, one-sided, and unfulfillable. My concern in what follows will be with the fourth element in this analysis – or what I shall refer to simply as Løgstrup’s unfulfillability thesis. My discussion addresses three specific questions: Is it coherent to suppose that the ethical demand is unfulfillable? Why does Løgstrup hold that the ethical demand is unfulfillable? What kind of response is appropriate in the face of an unfulfillable ethical demand? (shrink)

THE PROBLEM OF THE INTERPRETATION OF HAMANN Johann Georg Hamann is an intriguing but poorly known figure in the contemporary intellectual world. Yet this is the man whom Kierkegaard saluted as "Emperor!", whose writings were to have been arranged for publication by none other than Goethe himself, and whom Dilthey numbered among the primordial figures in the rise of modern historical consciousness. There are reasons for the persistence of this general ignorance. Hamann is deep. And, in addition, there is his (...) forbidding style. The readers of Kierkegaard and Dilthey, two other giants who them selves achieved late recognition, have not had to face this kind of imposing obstacle. Not only does Hamann expect his readers to handle themselves in deep water, but to intuit their way between his ideas which bob up like islands with no visible connection between them. Like Kierkegaard too, Hamann has had his troubles with the public. He himself referred to the hope that he would be understood by a "better posterity". In fact only the last few years have seen the printing of some of his more controversial writings, in particular his theories on the nature of human sexuality. (shrink)

The usual completeness theorem for first-order logic is extended in order to allow for a natural incorporation of real analysis. Essentially, this is achieved by building in the set of real numbers into the structures for the language, and by adjusting other semantical notions accordingly. We use many-sorted languages so that the resulting formal systems are general enough for axiomatic treatments of empirical theories without recourse to elements of set theory which are difficult to interprete empirically. Thus we provide a (...) way of applying model theory to empirical theories without tricky detours. Our frame is applied to axiomatizations of three empirical theories: classical mechanics, phenomenological thermodynamics, and exchange economics. (shrink)

In 385B-C of the Cratylus, Plato appears to be formulating a version of the correspondence theory of truth, in such a way that it applies not only to discourse, but to individual names as well. However commentators who have remarked on this passage, either take exception to the reasoning, or find it necessary to interpret the conclusion with qualifications that Plato never could have intended. Richard Robinson, for example, on p.328 of “A Criticism of Plato’s Cratylus”, sums up the argument (...) thus:... since statements have a truthvalue, their parts, including names, must have a truthvalue too. Therefore names are true or false.and criticises it for involving a fallacy of division. Lorenz and Mittelstrasse, by contrast, construe the argument as validly proceeding from the true-false distinction of sentences to a corresponding true-false distinction of their parts. (shrink)

The general significance of Ovid's Apollo-Dapbne within its immediate context seems plain enough. Ovid's technique, as Otis remarks, is to set epic pretensions beside elegiac behaviour and thus to show a struggle between incompatible styles of life and poetry. Yet the episode still poses certain problems. These mainly concern the significance of the story within the wider context of the opening of Ovid's poem. One difficulty is hinted at by Otis himself. He observes that with the Apollo-Dapbne and Jupiter-10 Ovid (...) has ‘deflated his divine prologue’. Yet elsewhere3 Otis remarks that in one sense the gap between the behaviour of the gods in the concilium deorum and their philandering in the Daphne and Io stories is very slight. (shrink)

The Platonic MS. Vat. gr. 225 contains tetr. I, VI. 3, 4, II–IV, while its companion volume in the same hand Vat. gr. 226 contains V–VI. 2, VIII. 3, VII, Spp., VIII. 1, 2. Posts states that for tetr. I and VI. 3 A is close to Vind. suppl. gr. 7 and thereafter derives from the Clarkianus . I am here concerned only with the testimony of Δ in. 2 . This manuscript has been largely ignored by commentators and editors. (...) Schanz does not quote it, nor does Bekker . Alline is scornful about it. Neither Burnet nor Croiset quotes it—and indeed Burnet claims that it is merely an interpolated apograph of W. Stallbaum seems to be the only editor who quotes it for Apol. This appears to be an unwarranted neglect since A has, in fact, a good claim to be considered as a primary witness in this dialogue. (shrink)

The influence of John Locke's thought in Europe and America rests largely on his articulation and defence of a liberal political philosophy, and in his formulation of a theory of knowledge where experience and environment provide the exclusive starting points in the educational process. Generally he continues to be associated with the eighteenth-century 'Age of Reason' or Enlightenment, where the malleability of human nature, together with the inherent dignity and freedom of the individual, were placed at the forefront of reform (...) efforts on both sides of the Atlantic. This book argues that while Locke's concern for the enhancement of individual autonomy, religious toleration, and constitutional government was indeed fundamental to later generations, Locke himself viewed the improvement of the human condition in terms of its relationship to the ancient Christian story. In particular, Locke's larger integration 'project' was to assist his contemporaries in their efforts both to recognise and to secure the greatest happiness. Locke, in other words, was chiefly interested in life beyond the grave, in salvation, and his recommendations for the reform of politics, education and religion were all viewed by the author as instrumental to the chief business of humankind. Locke's universe was a God-directed one, where human's were set specific tasks and where reward was contingent upon behaviour in this life. Locke viewed himself as a defender of the historical faith, and his work was devoted to broadening the opportunities for individual salvation. (shrink)

Since Teuffel's Römische Literatur mentions s.v. Varius the famous entry in the Monte Cassino MS. incipit thvestes varii, but ignores its occurrence in a Benevento MS. , it may be well to give some account of the latter codex. For I read with amusement a recent article in this journal in which the writer severely censured Mr. Garrod's ignorance of the entry in Paris 7530, but revealed his own ignorance by assuming that it was the scribe of the Paris MS. (...) who had the lost tragedy of Varius before him. (shrink)

Sartre rationalizes sexuality much like Plato. Rationalization here refers to the way Sartre tries to facilitate explanation by changing the terms of the discussion from sexual to nonsexual concepts. As a philosophy which, above all, highlights those features of human existence which seem most resistant to explanation, one would expect existentialism to highlight sexuality as a category that is crucial for considering human existence. Descartes comes immediately to mind when one focuses on Sartre's major categories. In Sartre's case however, it (...) is not mind and matter but consciousness and its opposite: "nothingness" and "being." This irreducible dualism is the key to the trouble human beings have with existence. Humans try to deal with the tensions implied by this dualism by trying to pretend people are not subjects but objects. Sartre calls this "bad faith." He begins by attempting to take human sexuality seriously as a fundamental category, but ends by abandoning the effort in favor of other substitutes. (shrink)

This book argues that the ability to integrate biological and psychological levels of understanding is inhibited by two important issues. Ideas about the autonomic nervous system are integrated with those from the author's previous text A Basic Theory of Neuropsychoanalysis.

Bovine fetuin, the first fetal protein to be described, has recently been shown to be a species homologue of a well known human plasma protein ‐ α2HS glycoprotein (α2HS). The fetuins are now known to be members of the cystatin superfamily. The structural properties of the six fetuins that have been fully sequenced are compared. Despite the structural homology of these proteins, their described properties in the literature make them appear to be quite different. The diverse in vitro properties claimed (...) for fetuin/α2HS are reviewed. In vivo, fetuins are involved in the acute phase response. In development, in all species studied so far, fetuins are present in a specific cell population that forms the developing neocortex. The possible functional significance of this distribution is discussed. (shrink)

In making the following suggestions I have assumed the chronological possibility of allusions in the Aetia Prologue on the one hand to the quarrel with Apollonius Rhodius, and on the other to Arsinoe II. . That such a combination is possible is maintained by Rostagni in Rivista di Filologia, 1928, pp. 1 sqq. The textual supplements offered here, while intended to support the double hypothesis, differ from his in some points; notably in regard to the question of where the allusion (...) to Arsinoe is to be introduced into the text of Callimachus . It need hardly be said that the supposed allusions to the queen and to the rival poet do not necessarily stand or fall together. In the case of the former it might not be altogether incredible that such an allusion should have been made after her death; whilst the most obvious consequence in regard to Apollonius would be that, if a date before 270 B.C. be accepted for the Prologue, his birth would have to be placed as early as possible—say, 295–290 B.C. However this may be, it is here sought to complete, in the above sense, certain passages in the Prologue with the aid of the British Museum Scholiast . In regard to the latter a fresh study of the original text by the editor has been utilized, to say nothing of his valuable suggestions and criticisms; in the case of P. the facsimile in Ox. Pap. XVII. is depended upon. The silence of S. on some of the supposed points may fairly be adduced in objection to them; but it may be noted that he does not comment on Πυγμαίων , and that his exposition, where it can be checked, seems to be somewhat hasty and unbalanced. Further, we do not know what may have preceded the portion of his work which has survived. (shrink)

The construction assumed for the first sentence in this passage is that adopted by Verrall and Headlam, apart from some differences in detail. It seems unlikely that δών can refer to what precedes, as some have thought; for it can hardly be supposed that the poet, who is using speed and economy , would pause to tell us that the great Seer merely ‘sees’ two distinctively coloured birds which ‘have appeared near by in a conspicuous station’ compare Homer's method . (...) Also it would involve us in the doubtful construction Ατρεϊδας έδάη λαγοδαίτας for ‘he knew the . to be the λ.’ ; the nearest parallel to this would appear to be Xen. Anab. 1. 7. 4 οους γνώσεσθε τοùς νθρπονς, where the adjective makes some difference. (shrink)

This study compared the family characteristics, victimization histories, and number of perpetration offenses of juvenile offenders who admitted to having had sex with animals to juvenile offenders who did not. The study found that 96% of the juveniles who had engaged in sex with nonhuman animals also admitted to sex offenses against humans and reported more offenses against humans than other sex offenders their same age and race. Those juveniles who had engaged in sex with animals were similar to other (...) sex offenders in that they also came from families with less affirming and more incendiary communication, lower attachment, less adaptability, and less positive environments. Those juveniles who had engaged in sex with animals reported victimization histories with more emotional abuse and neglect and a higher number of victimization events than other offenders. This would seem to indicate that sex with animals may be an important indicator of potential or co-occurring sex offenses against humans and may be a sign of severe family dysfunction and abuse that should be addressed in the arenas of psychological intervention, juvenile justice programs, and public policy. (shrink)

Originally published in 1936 as part of the 'Medieval Epics' series for Cambridge Contact Readers, this book contains the stories of the folk heroes Dietrich von Bern and Tannhäuser in German. The text is illustrated with beautiful black and white drawings, and a vocabulary list is provided at the end of the volume. This book will be of value to anyone with an interest in German folklore or the history of German education in Britain.

The Research Excellence Framework of the Higher Education Funding Council for England is taking place in 2013, its three key elements being outputs, impact, and “quality of the research environment”. Impact will be assessed using case studies that “may include any social, economic or cultural impact or benefit beyond academia that has taken place during the assessment period.”1 Medical ethics in the UK still does not have its own cognate assessment panel—for example, bioethics or applied ethics—unlike in, for example, Australia. (...) Several researchers in medical ethics have reported to the Institute of Medical Ethics that during the internal preliminary stage of the Research Excellence Framework several medical schools have decided to include only research that entails empirical data gathering. Thus, conceptual papers and ethical analysis will be excluded. The arbitrary exclusion of reasoned discussion of medical ethics issues as a proper subject for medical research unless it is based on empirical data gathering is conceptually mistaken. “Empirical ethics” is, of course, a legitimate component of medical ethics research, but to act as though it is the only legitimate component suggests, at best, a partial understanding of the nature of ethics in general and medical ethics in particular. It also mistakenly places medicine firmly on only one side of the science/humanities “two cultures” divide instead of in its rightful place bridging the divide. Given the emphasis by the General Medical Council on medical ethics in properly preparing “tomorrow’s doctors,” we urge medical schools to find a way of using the upcoming Research Excellence Framework to highlight the expertise residing in their ethicist colleagues. We are confident that appropriate assessment will reveal work of high quality that can be shown to have social and cultural impact and benefit beyond academia, as required by the framework. (shrink)

In the above article endeavours have been made to outline the development of Biology in the Netherlands during the last 20 years. At Utrecht under the supervision of A. A. Pulle studies have been made of the flora in the Malayan Archipelago. Internationally Dirks and Verdoorn in particular have acquired great merit in Botany. In 1935 the sixth International Botanical Congress was organised in Amsterdam.

In modern approaches to phonology a lack of clarity exists on the issue of whether phonetic facts are psychological or physical realities. The results from an experiment suggest that phonetic facts can be considered as psychological realities, but with the restriction that they can take acoustical shape. More specifically, the syntactic material consisted of ambiguous French sentences of the following sort: On a tourné ce film intéressant pour les étudiants. They were spoken in disambiguating contexts, without the readers noticing the (...) ambiguities, and without context, but with the instruction to make a conscious effort to disambiguate. By tape splicing, the contexts were removed from the context-embedded sentences. Twenty-eight native speakers of French listened to the sentences and judged whether one or the other meaning had been intended by the speaker. Subjects performed significantly above chance: 60% correct identifications for context-embedded sentences, 75% for context-free sentences. Pitch-amplitude analyses were made to determine the acoustical differences involved. (shrink)

The abbreviation-symbols of the Romans, found in ancient uncial MSS., may be roughly divided into three classes: Those peculiar to juristic writing, e.g. R.P. ‘res priuata’ , Q.D.R.A. ‘qua de re agitur.’ They are properly called ‘notae iuris.’ They abound in the famous Verona MS. of Gaius. A few used in histories, etc., e.g. R.P. 'respublica' , Q. ‘Quintus’ . Valerius Probus, who compiled a manual of ancient Notae, calls this class ‘notae publicae’. They appear in such MSS. as the (...) codex Puteanus of Livy ; and since they have been transferred into modern editions of the Latin historians, etc., no one is at a loss to interpret them nowadays, although they puzzled mediaeval scribes. Symbols of ordinary words of frequent occurrence in any type of literature, e.g. Q. ‘que.’ It is this class which is the subject of this article. (shrink)

Amph. prol. 90–91. In the Amphitruo Plautus runs great risk of giving oflence by bringing Jupiter on the stage. In the prologue he conciliates the audience by saying that this Jupiter is no god but a mere actor. : 26 sqq. Etenim ille quois hue iussu uenio Iuppiter Non minu' quam uostrum quiuis formidat malum: Humana matre natus, humano patre, Mirari non est aequom sibi si praetimet.